An AChE inhibitor; is more active at ocular acetylcholinesterases than those isolated from rabbit brain

Echothiophate (iodide) – 5 mg

Brand:
Cayman
CAS:
513-10-0
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Echothiophate is an organophosphate and acetylcholinesterase (AChE) inhibitor.{37301} It is more active at ocular acetylcholinesterases than those isolated from rabbit brain, liver, or blood. In vivo, topical ocular administration of echothiophate (0.125 and 0.25% w/v) reduces intraocular pressure and induces miosis in dogs with normotensive eyes and those with inherited glaucoma.{37302} It also induces formation of subcapsular cataracts in cynomolgus monkeys.{37303} Formulations containing echothiophate have been used for the treatment of glaucoma.  

 

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Description

An AChE inhibitor; is more active at ocular acetylcholinesterases than those isolated from rabbit brain, liver, or blood; reduces intraocular pressure and induces miosis in dogs with normotensive eyes and those with inherited glaucoma following topical administration of a 0.125 or 0.25% w/v solution; induces formation of subcapsular cataracts in cynomolgus monkeys

Formal name: 2-[(diethoxyphosphinyl)thio]-N,N,N-trimethyl-ethanaminium, monoiodide

Synonyms: 

Molecular weight: 383.2

CAS: 513-10-0

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors|Acetylcholine Turnover||Research Area|Neuroscience|Ophthalmology

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