A prodrug of epinephrine; reduces bovine primary trabecular meshwork cell density in vitro (IC50 = 115 µM); induces a fibroblast-like morphology and actin cytoskeleton disruption in cultured bovine primary trabecular meshwork cells (103 µM); enhances calcium signaling and induces cytotoxicity in cultured bovine corneal endothelial cells (28 µM); suppresses primary human corneal keratinocyte proliferation in vitro (280 µM)

Dipivefrin (hydrochloride) – 50 mg

Brand:
Cayman
CAS:
64019-93-8
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Dipivefrin is a prodrug of epinephrine that is hydrolyzed by cholinesterase and other esterases in the cornea to epinephrine.{36428} It reduces the density of cultured bovine primary trabecular meshwork cells (IC50 = 115 µM).{36424} Additionally, it induces an elongated, fibroblast-like morphology and disrupts the actin cytoskeleton in bovine primary trabecular meshwork cells when used at a concentration of 103 µM.{36424} In cultured bovine corneal endothelial cells, dipivefrin (28 µM) enhances calcium signaling and induces cytotoxicity.{36426,36425} Dipivefrin also suppresses primary human corneal keratinocyte proliferation when used at a concentration of 280 µM.{36427} Formulations containing dipivefrin have been used alone and in combination with β-adrenergic receptor antagonists for the treatment of glaucoma.  

 

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Description

A prodrug of epinephrine; reduces bovine primary trabecular meshwork cell density in vitro (IC50 = 115 µM); induces a fibroblast-like morphology and actin cytoskeleton disruption in cultured bovine primary trabecular meshwork cells (103 µM); enhances calcium signaling and induces cytotoxicity in cultured bovine corneal endothelial cells (28 µM); suppresses primary human corneal keratinocyte proliferation in vitro (280 µM)

Formal name: 2,2-dimethyl-propanoic acid, 1,1′-[4-[1-hydroxy-2-(methylamino)ethyl]-1,2-phenylene] ester, monohydrochloride

Synonyms: 

Molecular weight: 387.9

CAS: 64019-93-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Ophthalmology

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