A NNRTI; selectively inhibits HIV-1 reverse transcriptase over DNA polymerase α and δ in vitro (IC50s = 0.26

Delavirdine (mesylate) – 1 mg

Brand:
Cayman
CAS:
147221-93-0
Storage:
-20
UN-No:
Non-Hazardous - /

Delavirdine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that selectively inhibits HIV-1 reverse transcriptase over DNA polymerase α and δ in vitro (IC50s = 0.26, 440, and >550 μM, respectively).{40767} It inhibits growth of clinical isolates of HIV-1 (ED50s = 50 value of 0.066 μM. Delavirdine also inhibits growth of L. infantum promastigotes (IC50 = 26.1 μM).{40768} Formulations containing delavirdine have been used in the treatment of HIV.  

 

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SKU: 24026 - 1 mg Category:

Description

A NNRTI; selectively inhibits HIV-1 reverse transcriptase over DNA polymerase α and δ in vitro (IC50s = 0.26, 440, and >550 μM, respectively); blocks replication of 25 primary HIV-1 isolates (mean ED50 = 0.066 μM); inhibits growth of L. infantum promastigotes (IC50 = 26.1 μM)

Formal name: N-[2-[[4-[3-[(1-methylethyl)amino]-2-pyridinyl]-1-piperazinyl]carbonyl]-1H-indol-5-yl]-methanesulfonamide, monomethanesulfonate

Synonyms: 

Molecular weight: 552.7

CAS: 147221-93-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Antivirals|Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs)||Product Type|Biochemicals|Small Molecule Inhibitors|Reverse Transcriptases||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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