An Na+/K+ ATPase inhibitor (IC50 = 5 nM in isolated rat pinealocytes); inhibition results in loss of the transmembrane Na+ gradient

Acetyldigitoxin – 1 mg

Brand:
Cayman
CAS:
1111-39-3
Storage:
-20
UN-No:
Non-Hazardous - /

Acetyldigitoxin is cardiac glycoside and an inhibitor of the Na+/K+ ATPase with an IC50 value of 5 nM in isolated rat pinealocytes.{41362} This inhibition results in loss of the transmembrane Na+ gradient, which decreases activity of the Na+/Ca2+ exchanger, increasing intracellular calcium levels, inotropy, and cardiac force.{29469,38192} Formulations containing acetyldigitoxin have been used for the treatment of heart failure and chronic atrial fibrillation.  

 

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SKU: 24024 - 1 mg Category:

Description

An Na+/K+ ATPase inhibitor (IC50 = 5 nM in isolated rat pinealocytes); inhibition results in loss of the transmembrane Na+ gradient, which decreases activity of the Na+/Ca2+ exchanger, increasing intracellular calcium levels, inotropy, and cardiac force

Formal name: (3β,5β)-3-[(O-3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-14-hydroxy-card-20(22)-enolide

Synonyms: 

Molecular weight: 807

CAS: 1111-39-3

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors|ATPases||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cardiovascular System|Cardiovascular Diseases|Heart Failure||Research Area|Cardiovascular System|Heart|Myocardial Contractility

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