A polyamine chelating agent; reduces the amount of a copper-albumin complex and increases formation of low molecular weight complexes in a dialysis assay in a concentration-dependent manner; mobilizes copper ex vivo in human sera

Trientine (hydrochloride) – 1 g

Brand:
Cayman
CAS:
38260-01-4
Storage:
-20
UN-No:
Non-Hazardous - /

Trientine is a polyamine chelating agent.{38494} It reduces the amount of a copper-albumin complex and increases formation of low molecular weight complexes in a dialysis assay in a concentration-dependent manner. Trientine mobilizes copper ex vivo in human sera, increasing the supernatant percentage in an analytical ultracentrifugation experiment. In vivo, trientine (40 mg/kg, i.v.) mobilizes copper in the kidneys, but not the liver, to increase urinary excretion in rats. Trientine also decreases nickel accumulation in the liver, kidney, and spleen in mice injected with nickel chloride.{38495} Formulations containing trientine have been used to reduce copper accumulation in patients with Wilson’s disease.  

 

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SKU: 24000 - 1 g Category:

Description

A polyamine chelating agent; reduces the amount of a copper-albumin complex and increases formation of low molecular weight complexes in a dialysis assay in a concentration-dependent manner; mobilizes copper ex vivo in human sera, increasing the supernatant percentage in an analytical ultracentrifugation experiment; mobilizes copper in the kidneys, but not the liver, to increase urinary excretion in rats when administered at a dose of 40 mg/kg, i.v.; decreases nickel accumulation in the liver, kidney, and spleen in mice injected with nickel chloride,

Formal name: N1,N2-bis(2-aminoethyl)-1,2-ethanediamine, dihydrochloride

Synonyms:  Triethylenetetramine

Molecular weight: 219.2

CAS: 38260-01-4

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Metal Chelators||Research Area|Neuroscience||Research Area|Toxicology

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