A halogenated ether with anesthetic properties; enhances the activity of GABAA and glycine receptors; inhibits activity of nAChRs and glutamate receptors; enhances responses of α2β1 subunit-containing GABAA and α1 subunit-containing glycine receptors in HEK293 cells (EC50s = 0.45 and 0.36 mM

Sevoflurane – 5 g

Brand:
Cayman
CAS:
28523-86-6
Storage:
-20
UN-No:
Non-Hazardous - /

Sevoflurane is a halogenated ether with anesthetic properties.{41455} It enhances the activity of GABAA and glycine receptors and inhibits the activity of nicotinic acetylcholine receptors (nAChRs) and glutamate receptors. Sevoflurane enhances the responses of α2β1 subunit-containing GABAA and α1 subunit-containing glycine receptors at submaximal agonist concentrations in HEK293 cells (EC50s = 0.45 and 0.36 mM, respectively).{41456} Sevoflurane (360 µM) also increases the amplitude of GABAA receptor responses to GABA stimulation for receptors with an α1β2γ2 subunit composition.{41457} It inhibits binding of the high affinity nicotinic agonist epibatidine to nAChRs in mouse brain membranes (IC50 = 0.77 mM).{41458} Formulations containing sevoflurane have been used in the induction and maintenance of general anesthesia.  

 

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SKU: 23996 - 5 g Category:

Description

A halogenated ether with anesthetic properties; enhances the activity of GABAA and glycine receptors; inhibits activity of nAChRs and glutamate receptors; enhances responses of α2β1 subunit-containing GABAA and α1 subunit-containing glycine receptors in HEK293 cells (EC50s = 0.45 and 0.36 mM, respectively); increases the amplitude of α1β2γ2 subunit-containing GABAA receptor responses to GABA stimulation (360 µM); inhibits binding of the high affinity nicotinic agonist epibatidine to nAChRs in mouse brain membranes (IC50 = 0.77 mM)

Formal name: 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)-propane

Synonyms:  Fluoromethyl 1,1,1,3,3,3-Hexafluoro-2-propyl ester|Fluoromethyl 1,1,1,3,3,3-Hexafluoroisopropyl ester

Molecular weight: 200.1

CAS: 28523-86-6

Purity: ≥95%

Formulation: A neat oil

Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Neuroscience

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