A prodrug from of cefamandole; inhibits the growth of E. cloacae

Cefamandole Nafate – 1 g

Brand:
Cayman
CAS:
42540-40-9
Storage:
-20
UN-No:
Non-Hazardous - /

Cefamandole nafate is a formate ester prodrug form of the cephalosporin antibiotic cefamandole (Item No. 18138).{43407} Cefamandole nafate inhibits the growth of E. cloacae, E. coli, K. pneumoniae, P. mirabilis, P. vulgaris, P. morganii, S. aureus, and S. pyogenes in vitro (MICs = 0.1-50 μg/ml). In vivo, cefamanadole nafate protects against E. cloacae, E. coli, K. pneumoniae, P. mirabilis, P. vulgaris, P. morganii, S. aureus, and S. pyogenes infection in mice (ED50s = 0.3-334 mg/kg). Cefamandole (500 mg/kg) also protects against nephrotoxicity induced by the aminoglycoside antibiotic tobramycin (Item No. 14596) in rats.{43408}  

 

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SKU: 23988 - 1 g Category:

Description

A prodrug from of cefamandole; inhibits the growth of E. cloacae, E. coli, K. pneumoniae, P. mirabilis, P. vulgaris, P. morganii, S. aureus, and S. pyogenes in vitro (MICs = 0.1-50 μg/ml); protects against E. cloacae, E. coli, K. pneumoniae, P. mirabilis, P. vulgaris, P. morganii, S. aureus, and S. pyogenes infection in mice (ED50s = 0.3-334 mg/kg); protects against tobramycin-induced nephrotoxicity at 500 mg/kg

Formal name: (6R,7R)-7-[[(2R)-2-(formyloxy)-2-phenylacetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, monosodium salt

Synonyms:  NSC 299588

Molecular weight: 512.5

CAS: 42540-40-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Cephalosporins||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Pneumonia

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