A synthetic progestogen; reduces TNF-α-induced hypertension and decreases renal ET-1 production in pregnant rats (3.32 mg/kg); reduces RUPP-induced hypertension and production of TNF-α and IL-6 in pregnant rats; prevents L-NAME-induced preterm birth in pregnant mice

Hydroxyprogesterone Caproate – 250 mg

Brand:
Cayman
CAS:
630-56-8
Storage:
-20
UN-No:
Non-Hazardous - /

Hydroxyprogesterone caproate is a synthetic progestogen.{39556} In vivo, hydroxyprogesterone caproate (3.32 mg/kg) reduces TNF-α-induced hypertension and decreases renal endothelin-1 (ET-1) production in pregnant rats. It reduces hypertension and production of TNF-α and IL-6 induced by reduction in uteroplacental perfusion (RUPP) in pregnant rats.{39557} Hydroxyprogesterone caproate also prevents preterm birth induced by L-NAME (Item No. 80210) in pregnant mice.{39558} Formulations containing hydroxyprogesterone caproate have been used for the prevention of preterm birth.  

 

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SKU: 23978 - 250 mg Category:

Description

A synthetic progestogen; reduces TNF-α-induced hypertension and decreases renal ET-1 production in pregnant rats (3.32 mg/kg); reduces RUPP-induced hypertension and production of TNF-α and IL-6 in pregnant rats; prevents L-NAME-induced preterm birth in pregnant mice ,

Formal name: 17-[(1-oxohexyl)oxy]-pregn-4-ene-3,20-dione

Synonyms:  17-Caproxyprogesterone|17α-hydroxy Progesterone Caproate|Hormofort|HPC|Hydroxyprogesterone Hexanoate|NSC 17592|Progesterone Caproate

Molecular weight: 428.6

CAS: 630-56-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins||Research Area|Endocrinology & Metabolism|Reproductive Biology

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