A dicarboxylic acid with diverse biological activities; a competitive inhibitor of tyrosinase

Azelaic Acid – 100 g

Brand:
Cayman
CAS:
123-99-9
Storage:
-20
UN-No:
Non-Hazardous - /

Azelaic acid is a naturally occurring and saturated dicarboxylic acid with diverse biological activities.{38830,38831,38832,38833,38834} It is a competitive inhibitor of tyrosinase, NADH dehydrogenase, succinic dehydrogenase, and reduced ubiquitinone:cytochrome C oxidoreductase in vitro.{38830,38831} Azelaic acid inhibits the growth and colony formation of B16 murine as well as HMB2 and SK32 human melanoma cells in a concentration-dependent manner but has no effect on CHO cells.{38832} It decreases DNA synthesis, induces mitochondrial damage and dilation of the rough endoplasmic reticulum (RER), and reduces growth of mouse keratinocytes in a dose- and time-dependent manner.{38833} Azelaic acid is bacteriostatic against S. epidermidis, S. aureus, S. capitis, P. acnes, P. avidum, P. mirabilis, and C. albicans in vitro (MICs = 0.03-0.25 M).{38834} Formulations containing azelaic acid have been used in the treatment of acne and hyperpigmentation disorders.  

 

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SKU: 23977 - 100 g Category:

Description

A dicarboxylic acid with diverse biological activities; a competitive inhibitor of tyrosinase, NADH dehydrogenase, succinic dehydrogenase, and reduced ubiquitinone:cytochrome C oxidoreductase in vitro; inhibits the growth and colony formation of B16 murine as well as HMB2 and SK32 human melanoma cells; decreases DNA synthesis, induces mitochondrial damage and dilation of the RER, and reduces growth of mouse keratinocytes; bacteriostatic against various microorganisms (MICs = 0.03-0.25 M),

Formal name: nonanedioic acid

Synonyms:  NSC 19493

Molecular weight: 188.2

CAS: 123-99-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Fatty Acids||Product Type|Biochemicals|Small Molecule Inhibitors|Oxidative Phosphorylation||Research Area|Cancer||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Fungal Diseases|Candidiasis

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