Terconazole – 100 mg

Brand:
Cayman
CAS:
67915-31-5
Storage:
-20
UN-No:
Non-Hazardous - /

Terconazole is an orally bioavailable broad-spectrum triazole antifungal agent that completely inhibits growth of T. rubrum, M. audouini, M. canis, and T. verrucosum, as well as some C. albicans and A. fumigatus strains and other fungi when used at a concentration of 100 μg/ml.{41683} It also has bacteriostatic activity against E. coli, P. aeruginosa, S. aureus, and S. pyogenes when used at a concentration of 100 μg/ml. Terconazole eliminates vaginal C. albicans candidiasis infection in 97% of rats when administered as a 1% topical ointment and in 50% of rats when orally administered at a dose of 10 mg/kg. It inhibits cytochrome P450 (CYP) isoforms involved in ergosterol biosynthesis, interfering with fungal cell membranes.{41684} It decreases synthesis of 14α-desmethyl sterols and increases synthesis of methylated sterols in C. albicans (IC50 = 3 nM).{41685} Formulations containing terconazole have been used in the treatment of candidiasis of the vulva and vagina.  

 

Available on backorder

SKU: 23959 - 100 mg Category:

Description

An orally bioavailable broad-spectrum triazole antifungal agent; completely inhibits growth of T. rubrum, M. audouini, M. canis, and T. verrucosum, as well as some C. albicans and A. fumigatus strains and other fungi (100 μg/ml); bacteriostatic against E. coli, P. aeruginosa, S. aureus, and S. pyogenes (100 μg/ml); eliminates vaginal C. albicans candidiasis infection in 97% of rats (1%, topical); eliminates vaginal C. albicans candidiasis infection in 50% of rats (10 mg/kg, oral); decreases synthesis of 14α-desmethyl sterols and increases synthesis of methylated sterols in C. albicans (IC50 = 3 nM)


Formal name: 1-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-(1-methylethyl)-rel-piperazine

Synonyms:  (±)-Terconazole|NSC 331942|R-42470

Molecular weight: 532.5

CAS: 67915-31-5

Purity: ≥98%

Formulation: A crystalline solid


Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antifungals|Triazoles||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Fungal Diseases|Aspergillosis||Research Area|Infectious Disease|Fungal Diseases|Candidiasis