Description
A semisynthetic β-lactam antibiotic; active against clinical isolates of methicillin-susceptible S. aureus and penicillin-susceptible S. pneumoniae, as well as group A, group B, and viridans group streptococci in vitro (MIC90s = 0.06-2 µg/ml); less effective toward other bacteria (MIC90 = >16 µg/ml for S. epidermidis, S. haemolyticus, E. faecalis, E. faecium, MRSA, and penicillin-intermediate and -resistant S. pneumoniae); targets the bacterial cell wall; inhibits S. pneumoniae penicillin-binding proteins 1a, 1b, 2a, 2b, and 3 in vitro (IC50s = 0.17-1.75 µM); inhibits growth of S. aureus in a thigh model of infection in mice (ED50 = 45.19 mg/kg, s.c.)
Formal name: (2S,5R,6R)-3,3-dimethyl-6-[[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, monosodium salt
Synonyms: Micropenin|NSC 527712|SQ16423
Molecular weight: 423.4
CAS: 1173-88-2
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Antibiotics|Penicillins||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|MRSA||Research Area|Infectious Disease|Bacterial Diseases|Pneumonia
