A non-steroidal androgen receptor antagonist; reverses testosterone-induced increases in cell proliferation in mouse mammary carcinoma cells in vitro (IC50 = 412 nM); inhibits testosterone propionate-induced prostate growth in rats (2.5 mg/kg)

Nilutamide – 1 g

Brand:
Cayman
CAS:
63612-50-0
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Nilutamide is a non-steroidal antiandrogen that is an antagonist of the androgen receptor.{41485} It reverses testosterone-induced increases in cell proliferation with an IC50 value of 412 nM in mouse mammary carcinoma cells in vitro.{41484} It has antiandrogenic activity in both intact and castrated rats, inhibiting testosterone propionate-induced prostate growth when administered at a dose of 2.5 mg/kg.{41486} Formulations containing nilutamide have been used in combination with surgical castration in the treatment of metastatic prostate cancer.  

 

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SKU: 23953 - 1 g Category:

Description

A non-steroidal androgen receptor antagonist; reverses testosterone-induced increases in cell proliferation in mouse mammary carcinoma cells in vitro (IC50 = 412 nM); inhibits testosterone propionate-induced prostate growth in rats (2.5 mg/kg)

Formal name: 5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-2,4-imidazolidinedione

Synonyms:  RU-23908

Molecular weight: 317.2

CAS: 63612-50-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Androgens

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