A water-soluble prodrug form of isavuconazole; increases survival in rat models of azole-susceptible and -resistant A. fumigatus infection (0.25-512 mg/kg per day); reduces fungal burden and organism-mediated pulmonary injury and increases survival in a rabbit model of experimental invasive pulmonary aspergillosis (ISA-equivalent doses of 40-60 mg/kg)

Isavuconazonium (sulfate) – 500 µg

Brand:
Cayman
CAS:
946075-13-4
Storage:
-20
UN-No:
Non-Hazardous - /

Isavuconazonium is a water-soluble prodrug form of the azole antifungal isavuconazole (ISA).{40775} Oral administration of isavuconazonium increases survival in rat models of azole-susceptible and -resistant A. fumigatus infection when administered at doses ranging from 0.25 to 512 mg/kg per day (ISA-equivalent = 0.12-245.8 mg/kg per day). Isavuconazonium reduces fungal burden and organism-mediated pulmonary injury and increases survival in a rabbit model of experimental invasive pulmonary aspergillosis when administered at ISA-equivalent doses ranging from 40 to 60 mg/kg.{40776}  

 

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Description

A water-soluble prodrug form of isavuconazole; increases survival in rat models of azole-susceptible and -resistant A. fumigatus infection (0.25-512 mg/kg per day); reduces fungal burden and organism-mediated pulmonary injury and increases survival in a rabbit model of experimental invasive pulmonary aspergillosis (ISA-equivalent doses of 40-60 mg/kg)

Formal name: N-methyl-[2-[[[1-[1-[(2R,3R)-3-[4-(4-cyanophenyl)-2-thiazolyl]-2-(2,5-difluorophenyl)-2-hydroxybutyl]-4H-1,2,4-triazolium-4-yl]ethoxy]carbonyl]methylamino]-3-pyridinyl]methyl ester, glycine, monosulfate

Synonyms: 

Molecular weight: 814.8

CAS: 946075-13-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antifungals|Triazoles||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Fungal Diseases|Aspergillosis

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