An ectoparasiticide and antipruritic agent; blocks mouse TRPV4 channel expressed in HEK293 cells in a calcium-dependent manner (IC50s = 223.5 and 15.5 μM in buffer containing 0 and 2 mM calcium

Crotamiton – 100 mg

Brand:
Cayman
CAS:
483-63-6
Storage:
-20
UN-No:
Non-Hazardous - /

Crotamiton is an ectoparasiticide and antipruritic agent.{41525,41526,41527} It blocks the mouse transient receptor potential vanilloid 4 (TRPV4) channel expressed in HEK293 cells in a calcium-dependent manner (IC50s = 223.5 and 15.5 μM in buffer containing 0 and 2 mM calcium, respectively).{41526} It inhibits scratching behavior in mice induced by the TRPV4 agonist GSK1016790A (Item No. 17289). Topical application of crotamiton (0.025 g of a 10% ointment) also inhibits scratching behavior in mice induced by histamine, serotonin (Item No. 14332), and the proteinase-activated receptor 2 (PAR2) agonist SLIGRL-NH2 (Item No. 16723).{41527} Formulations containing crotamiton have been used to eradicate scabies and in the treatment of symptomatic pruritic skin.  

 

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SKU: 23943 - 100 mg Category:

Description

An ectoparasiticide and antipruritic agent; blocks mouse TRPV4 channel expressed in HEK293 cells in a calcium-dependent manner (IC50s = 223.5 and 15.5 μM in buffer containing 0 and 2 mM calcium, respectively); inhibits scratching behavior in mice induced by the TRPV4 agonist GSK1016790A; topical application inhibits scratching behavior in mice induced by histamine, serotonin, and the PAR2 agonist SLIGRL-NH2 (0.025 g of a 10% ointment)

Formal name: N-ethyl-N-(2-methylphenyl)-2-butenamide

Synonyms:  N-Ethyl-o-Crotonotoluidide

Molecular weight: 203.3

CAS: 483-63-6

Purity: ≥95%

Formulation: A neat oil

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Pesticides||Research Area|Immunology & Inflammation|Allergy||Research Area|Infectious Disease

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