A non-competitive antagonist of nAChRs (IC50s = 390 and 350 nM

TMB 8 (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
53464-72-5
Storage:
-20
UN-No:
Non-Hazardous - /

TMB 8 is a non-competitive antagonist of nicotinic acetylcholine receptors (nAChRs) with IC50 values of 390 and 350 nM, respectively, for human muscle-type and α3β4 subunit-containing ganglionic nAChRs expressed in TE671/RD or SH-SY5Y cells.{38552} It inhibits nicotine-induced dopamine release from rat brain synaptosomes (IC50 = 480 nM). TMB 8 also reduces calcium availability in smooth and skeletal muscle, blocking the contractile response in isolated rabbit aortic strip when used at a concentration of 50 µM and inhibiting calcium influx and efflux in isolated guinea pig ileum when used at a concentration of 65 µM.{38553} It has been used in the study of intracellular calcium dynamics, particularly in smooth muscle.{38554,38555} TMB 8 also inhibits protein kinase C (PKC) activity in a dose-dependent manner.{38556}  

 

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SKU: 23928 - 5 mg Category:

Description

A non-competitive antagonist of nAChRs (IC50s = 390 and 350 nM, respectively, for human muscle-type and and α3β4 subunit-containing ganglionic nAChRs); an inhibitor of intracellular calcium availability in smooth and skeletal muscle; blocks the contractile response in isolated rabbit aortic strip when used at a concentration of 50 µM; inhibits calcium influx and efflux in isolated guinea pig ileum when used at a concentration of 65 µM; used in the study of intracellular calcium dynamics; dose-dependently inhibits PKC activity

Formal name: 3,4,5-trimethoxy-benzoic acid, 8-(diethylamino)octyl ester, monohydrochloride

Synonyms: 

Molecular weight: 432

CAS: 53464-72-5

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Kinase Inhibitors|PKC||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Cell Biology|Cell Signaling|Calcium Mobilization||Research Area|Neuroscience

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