An atypical antipsychotic; a dopamine D2 and D3 receptor antagonist (Kis = 5.37 and 6.45 nm

Zotepine – 50 mg

Brand:
Cayman
CAS:
26615-21-4
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Zotepine is an atypical antipsychotic.{38700} It is a dopamine D2 and D3 receptor antagonist (Kis = 5.37 and 6.45 nm, respectively) that reverses dopamine inhibition of forskolin-stimulated cAMP production in CHO cells expressing human D2 and D3 receptors. In vivo, zotepine inhibits head twitches induced by 5-hydroxy-L-tryptophan (Item No. 20539), a behavior mediated by the serotonin (5-HT) receptor subtype 5-HT2, in mice (ED50 = 0.13 mg/kg).{38701} It acts as an α2-adrenergic receptor (α2-AR) antagonist, reducing the hind limb flexor reflex stimulated by clonidine (Item No. 15949) in rats. Zotepine blocks gnawing behavior and body turning induced by apomorphine (Item No. 16094) and methamphetamine in rats.{38702} It also induces catalepsy and inhibits apomorphine-induced vomiting in dogs. Formulations containing zotepine have been used in the treatment of schizophrenia and acute mania.  

 

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SKU: 23909 - 50 mg Category:

Description

An atypical antipsychotic; a dopamine D2 and D3 receptor antagonist (Kis = 5.37 and 6.45 nm, respectively); inhibits head twitches induced by 5-hydroxy-L-tryptophan in mice (ED50 = 0.13 mg/kg); an α2-AR antagonist, reducing the clonidine-stimulated hind limb flexor reflex in rats; blocks apomorphine- and methamphetamine-induced gnawing behavior and body turning in rats; induces catalepsy and inhibits apomorphine-induced vomiting in dogs,

Formal name: 2-[(8-chlorodibenzo[b,f]thiepin-10-yl)oxy]-N,N-dimethyl-ethanamine

Synonyms: 

Molecular weight: 331.9

CAS: 26615-21-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Behavioral Neuroscience|Bipolar Disorder||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis

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