An α2-AR agonist; binds to α2-AR in calf cortex

Apraclonidine (hydrochloride) – 1 mg

Brand:
Cayman
CAS:
73218-79-8
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Apraclonidine is an α2-adrenergic receptor (α2-AR) agonist and structural analog of clonidine (Item No. 15949).{40474} It binds to α2-ARs in calf cortex, rat kidney, and rat spleen with IC50 values of 0.9, 4.3, and 4.2 nM, respectively. Apraclonidine also binds to α2-ARs in rat cerebral cortex, pig submandibular gland and lung tissue, and in dog kidney membrane (Kds = 0.87, 5.28, 1.30, and 5.25 nM, respectively).{40475,40476} It inhibits noradrenaline-stimulated contraction in guinea pig ileum and rabbit vas deferens (EC50s = 7.59 and 6.76 nM, respectively).{40477} Opthalmic formulations containing apraclonidine have been used to treat elevated intraocular pressure.  

 

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SKU: 23904 - 1 mg Category:

Description

An α2-AR agonist; binds to α2-AR in calf cortex, rat kidney, and rat spleen (IC50s = 0.9, 4.3, and 4.2 nM, respectively); binds to α2-AR in rat cerebral cortex membrane, pig submandibular gland and lung tissue, and dog kidney membrane (Kds = 0.87, 5.28, 1.30, and 5.25 nM, respectively); inhibits noradrenaline-stimulated contraction in guinea pig ileum and rabbit vas deferens (EC50s = 7.59 and 6.76 nM, respectively)

Formal name: 2,6-dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)-1,4-benzenediamine, monohydrochloride

Synonyms:  ALO 2145|AL0 2145

Molecular weight: 281.6

CAS: 73218-79-8

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Ophthalmology

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