A first generation sulfonylurea; inhibits SUR1-KIR6.2 (Kis = 22.9 and 14.2 µM

Acetohexamide – 100 mg

Brand:
Cayman
CAS:
968-81-0
Storage:
-20
UN-No:
Non-Hazardous - /

Acetohexamide is a first generation sulfonylurea that inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (KIR6.2) with Ki values of 22.9 and 14.2 µM in HEK293 cells transfected with the human receptor and in rat brain, respectively.{36318} It is metabolized to the hypoglycemic compound L-hydroxyhexamide in vivo.{36320,36319} Formulations containing acetohexamide have previously been used in the treatment of type 2 diabetes.  

 

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SKU: 23900 - 100 mg Category:

Description

A first generation sulfonylurea; inhibits SUR1-KIR6.2 (Kis = 22.9 and 14.2 µM, in HEK293 cells and rat brain, respectively); metabolized to the hypoglycemic compound L-hydroxyhexamide in vivo

Formal name: 4-acetyl-N-[(cyclohexylamino)carbonyl]-benzenesulfonamide

Synonyms: 

Molecular weight: 324.4

CAS: 968-81-0

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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