An NMDA modulator with antagonist or agonist effects depending on brain region

Acamprosate (calcium salt) – 100 mg

Brand:
Cayman
CAS:
77337-73-6
Storage:
-20
UN-No:
Non-Hazardous - /

Acamprosate is an acetylated derivative of the GABA analog homotaurine (tramiprosate; Item No. 20701).{36372} Despite its structural similarity to GABA, acamprosate does not act at GABAA receptors but does decrease paired-pulse inhibition of GABAA inhibitory post-synaptic currents (IPSCs) at short inter-stimulus intervals when used at a concentration of 300 µM, indicating that it may inhibit GABAB autoreceptor-mediated inhibition of GABA release.{36373,36371,36374} It is an NMDA receptor modulator with antagonist or agonist effects depending on brain region, receptor subunit composition, and other factors.{36374} Acamprosate (0.26 and 0.52 mmol/kg per day, i.p.) reduces voluntary intake of ethanol in rats, an effect that can be blocked by the GABA antagonist bicuculline (Item No. 11727). Formulations containing acamprosate have been used for the maintenance of alcohol abstinence.  

 

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Description

An NMDA modulator with antagonist or agonist effects depending on brain region, receptor composition, and other factors; an acetylated derivative of homotaurine; decreases paired-pulse inhibition of GABAA IPSCs, indicating that it may inhibit GABAB autoreceptor-mediated inhibition of GABA release (300 µM); reduces voluntary intake of ethanol in rats (0.26 and 0.52 mmol/kg per day, i.p.)

Formal name: 3-(acetylamino)-1-propanesulfonic acid, hemicalcium salt (2:1)

Synonyms:  N-acetyl Homotaurinate|N-acetyl Homotaurine

Molecular weight: 200.2

CAS: 77337-73-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Neuroscience|Behavioral Neuroscience|Addiction Research

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