A DYRK1A inhibitor (Ki = 180 nM; IC50 = 240 nM); selective for DYRK1A over MAOA and B (100 μM); inhibits DYRK1A phosphorylation of tau in COS-7 cells expressing EGFP-DYRK1A and EGFP-tau in a concentration-dependent manner; induces proliferation of human and rat β-cells and increases insulin secretion by human islets in vitro; reverses developmental deformities induced by DYRK1A overexpression in X. laevis embryos

INDY – 1 mg

Brand:
Cayman
CAS:
1169755-45-6
Storage:
-20
UN-No:
Non-Hazardous - /

INDY is an ATP-competitive inhibitor of dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A; Ki = 180 nM; IC50 = 240 nM).{38762} It is selective for DYRK1A over monoamine oxidase (MAO) A and B at concentrations up to 100 μM. INDY inhibits DYRK1A phosphorylation of tau in COS-7 cells expressing EGFP-DYRK1A and EGFP-tau in a concentration-dependent manner. It also restores signaling through nuclear factory of activated T cells (NFAT) and NFAT-dependent transcription in HEK293 cells overexpressing DYRK1A. In vivo, INDY reverses developmental deformities induced by DYRK1A overexpression in X. laevis embryos. INDY also induces proliferation of human and rat β-cells and increases insulin secretion by human islets in vitro.{38763}  

 

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SKU: 23895 - 1 mg Category:

Description

A DYRK1A inhibitor (Ki = 180 nM; IC50 = 240 nM); selective for DYRK1A over MAOA and B (100 μM); inhibits DYRK1A phosphorylation of tau in COS-7 cells expressing EGFP-DYRK1A and EGFP-tau in a concentration-dependent manner; induces proliferation of human and rat β-cells and increases insulin secretion by human islets in vitro; reverses developmental deformities induced by DYRK1A overexpression in X. laevis embryos,

Formal name: 1Z-(3-ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-2-propanone

Synonyms: 

Molecular weight: 235.3

CAS: 1169755-45-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Non-Receptor Tyrosine Kinases||Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Neuroscience

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