An inhibitor of lysosomal acid lipase (IC50 = 68 nM); selective for LAL over human pancreatic and bovine milk lipoprotein lipases up to a concentration of 10 µM; reduces cholesterol accumulation in lysosome-like storage organelles in NPC1-deficient GM03123 cells (0.01-10 µM)

Lalistat 1 – 1 mg

Brand:
Cayman
CAS:
501104-16-1
Storage:
-20
UN-No:
Non-Hazardous - /

Lalistat 1 is an inhibitor of lysosomal acid lipase (LAL; IC50 = 68 nM using purified human LAL).{36492} It is selective for LAL over human pancreatic and bovine milk lipoprotein lipases up to a concentration of 10 µM.{36493} Lalistat 1 (0.01-10 µM) reduces cholesterol accumulation in lysosome-like storage organelles in GM03123 human fibroblast cells deficient in NPC1, a membrane protein found in late endosomes, in a concentration-dependent manner but has little effect on cholesterol accumulation in NPC1-deficient CHO cells.  

 

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Description

An inhibitor of lysosomal acid lipase (IC50 = 68 nM); selective for LAL over human pancreatic and bovine milk lipoprotein lipases up to a concentration of 10 µM; reduces cholesterol accumulation in lysosome-like storage organelles in NPC1-deficient GM03123 cells (0.01-10 µM)

Formal name: 4-morpholinecarboxylic acid, 4-(1-piperidinyl)-1,2,5-thiadiazol-3-yl ester

Synonyms: 

Molecular weight: 298.4

CAS: 501104-16-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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