A prodrug of phenytoin; induces less tissue damage compared with two other phenytoin prodrugs in rats following s.c. and i.m. administration; has anticonvulsant activity in a mouse model of maximal electroshock seizures similar to that of phenytoin (ED50s = 16 and 8 mg/kg

Fosphenytoin (sodium salt) – 500 mg

Brand:
Cayman
CAS:
92134-98-0
Storage:
-20
UN-No:
Non-Hazardous - 2811 / 6.1

Fosphenytoin is a prodrug of phenytoin that is rapidly converted to phenytoin, a voltage-gated sodium channel blocker, in vivo.{39387,39386,39385} It induces less tissue damage compared with two other phenytoin prodrugs in rats following subcutaneous and intramuscular administration.{39387} Fosphenytoin has anticonvulsant activity in a mouse model of maximal electroshock seizures similar to that of phenytoin (ED50s = 16 and 8 mg/kg, respectively).{39386} It also has antiarrhythmic activity in isolated guinea pig atria and in anesthetized dogs. Formulations containing fosphenytoin have been used in the treatment of status epilepticus.  

 

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SKU: 23889 - 500 mg Category:

Description

A prodrug of phenytoin; induces less tissue damage compared with two other phenytoin prodrugs in rats following s.c. and i.m. administration; has anticonvulsant activity in a mouse model of maximal electroshock seizures similar to that of phenytoin (ED50s = 16 and 8 mg/kg, respectively); has antiarrhythmic activity in isolated guinea pig atria and in anesthetized dogs

Formal name: 5,5-diphenyl-3-[(phosphonooxy)methyl]-2,4-imidazolidinedione, disodium salt

Synonyms:  ACC-9653|Cl-982

Molecular weight: 406.2

CAS: 92134-98-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Cardiovascular System|Heart|Arrhythmia||Research Area|Neuroscience|Seizure Disorders

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