An inhibitor of the amphiphysin-clathrin interaction (IC50 = 12 μM); inhibits clathrin-mediated transferrin uptake in HeLa and U2OS cells (IC50s = 12-15 and 9.7 μM

Pitstop2 – 10 mg

Brand:
Cayman
CAS:
1332879-52-3
Storage:
-20
UN-No:
Non-Hazardous - /

Pitstop2 is an inhibitor of the interaction between the clathrin terminal domain and amphiphysin (IC50 = 12 μM).{20347} It inhibits clathrin-mediated transferrin uptake in HeLa and U2OS cells (IC50s = 12-15 and 9.7 μM, respectively). Pitstop2 inhibits HIV-1 entry and infectivity in HeLa reporter cell lines. It also inhibits clathrin-independent endocytosis of CD44, CD98, and CD147 in HeLa cells.{51182}  

 

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SKU: 23885 - 10 mg Category:

Description

An inhibitor of the amphiphysin-clathrin interaction (IC50 = 12 μM); inhibits clathrin-mediated transferrin uptake in HeLa and U2OS cells (IC50s = 12-15 and 9.7 μM, respectively); inhibits HIV-1 entry and infectivity in HeLa reporter cell lines; inhibits clathrin-independent endocytosis of CD44, CD98, and CD147 in HeLa cells

Formal name: N-[5-[(4-bromophenyl)methylene]-4,5-dihydro-4-oxo-2-thiazolyl]-1-naphthalenesulfonamide

Synonyms: 

Molecular weight: 473.4

CAS: 1332879-52-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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