An orally bioavailable skeletal muscle relaxant; inhibits the ability of mice to remain on a vertical ladder for 1 minute (ED50 = 15 mg/kg) and decreases forelimb grip strength by 35.9% (500 mg/kg); abolishes femoral nerve-stimulated polysynaptic reflex contractions of the cat tibialis anterior muscle and prolongs the mean refractory period of directly or indirectly stimulated skeletal muscle (200 mg/kg); inhibits human CAI over CAII (IC50s = 70 and ~80

Methocarbamol – 50 g

Brand:
Cayman
CAS:
532-03-6
Storage:
4
UN-No:
Non-Hazardous - /

Methocarbamol is an orally bioavailable skeletal muscle relaxant.{38705} In vivo, methocarbamol inhibits the ability of mice to remain on a vertical ladder for 1 minute (ED50 = 15 mg/kg) and decreases forelimb grip strength by 35.9% when administered at a dose of 500 mg/kg.{38705,38707} It abolishes femoral nerve-stimulated polysynaptic reflex contractions of the cat tibialis anterior muscle and prolongs the mean refractory period of directly or indirectly stimulated skeletal muscle when administered at a dose of 200 mg/kg.{38708} Methocarbamol also selectively inhibits human carbonic anhydrase (CA) isoform I over CAII (IC50s = 70 and ~80,000 μM, respectively).{38706} Formulations containing methocarbamol have been used to treat skeletal muscle spasms.  

 

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Description

An orally bioavailable skeletal muscle relaxant; inhibits the ability of mice to remain on a vertical ladder for 1 minute (ED50 = 15 mg/kg) and decreases forelimb grip strength by 35.9% (500 mg/kg); abolishes femoral nerve-stimulated polysynaptic reflex contractions of the cat tibialis anterior muscle and prolongs the mean refractory period of directly or indirectly stimulated skeletal muscle (200 mg/kg); inhibits human CAI over CAII (IC50s = 70 and ~80,000 μM, respectively),

Formal name: 3-(2-methoxyphenoxy)-1,2-propanediol, 1-carbamate

Synonyms:  AHR 85|Guaiacol Glyceryl Ether Carbamate,|Guaiphenesin Carbamate|NSC 170960

Molecular weight: 241.2

CAS: 532-03-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Neuroscience

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