A M1 and M2 muscarinic acetylcholine receptor antagonist (Kis = 3.16 and 44.7 nM

Dicyclomine (hydrochloride) – 1 g

Brand:
Cayman
CAS:
67-92-5
Storage:
-20
UN-No:
Non-Hazardous - /

Dicyclomine is an M1 and M2 muscarinic acetylcholine receptor antagonist (Kis = 3.16 and 44.7 nM, respectively).{41413} It inhibits inositol phosphate accumulation induced by the non-selective acetylcholine agonist carbamoylcholine (carbachol; Item No. 14486) in guinea pig cortex (Ki = 12 nM; pA2 = 7.88). Dicyclomine (10 mg/kg, i.v.) inhibits potassium-induced contraction of ileum, colon, and duodenum in anesthetized rats by 21.85, 30.81, and 37.86%, respectively.{41414} Formulations containing dicyclomine have been used to treat functional and irritable bowel syndrome and to relieve muscle spasms in the gastrointestinal tract.  

 

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SKU: 23867 - 1 g Category:

Description

A M1 and M2 muscarinic acetylcholine receptor antagonist (Kis = 3.16 and 44.7 nM, respectively); inhibits carbachol-stimulated inositol phosphate accumulation in guinea pig cortex (Ki = 12 nM; pA2 = 7.88); inhibits potassium-induced contraction of ileum, colon, and duodenum in anesthetized rats by 21.85, 30.81, and 37.86%, respectively (10 mg/kg, i.v.)

Formal name: [1,1′-bicyclohexyl]-1-carboxylic acid, 2-(diethylamino)ethyl ester, monohydrochloride

Synonyms:  Dicycloverine

Molecular weight: 346

CAS: 67-92-5

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area

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