An antagonist of muscarinic acetylcholine receptors (Kds = 0.25

Methylscopolamine (bromide) – 1 g

Brand:
Cayman
CAS:
155-41-9
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Methylscopolamine is an antagonist of muscarinic acetylcholine receptors (Kds = 0.25, 0.37, 0.23, 0.22, and 0.3 nM for M1-5 respectively).{37295} It inhibits oxotremorine-induced gastric ulcer formation and pupillary light reflex in rats (ED50s = 0.4 and 3.6 μg/kg, respectively).{37296} It also increases pupil diameter in rats with an ED200 value of 1.8 μg/kg. Formulations containing methylscopolamine have been used for the treatment of peptic ulcers, intestinal spasms, and motion sickness.  

 

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SKU: 23862 - 1 g Category:

Description

An antagonist of muscarinic acetylcholine receptors (Kds = 0.25, 0.37, 0.23, 0.22, and 0.3 nM for M1-5 respectively); inhibits oxotremorine-induced gastric ulcer formation and pupillary light reflex in rats (ED50s = 0.4 and 3.6 μg/kg, respectively); increases pupil diameter in rats with an ED200 value of 1.8 μg/kg

Formal name: (1α,2β,4β,5α,7β)-7-[(2S)-3-hydroxy-1-oxo-2-phenylpropoxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane, monobromide

Synonyms:  NSC 120606|NSC 61809|U-5036

Molecular weight: 398.3

CAS: 155-41-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Ophthalmology

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