A cephalosporin antibiotic; inhibits the growth of both Gram-positive and Gram-negative bacteria; inhibits the growth of E. coli

Cefprozil – 25 mg

Brand:
Cayman
CAS:
92665-29-7
Storage:
-20
UN-No:
Non-Hazardous - /

Cefprozil is an orally bioavailable, second generation, broad-spectrum cephalosporin antibiotic that inhibits the growth of both Gram-positive and Gram-negative bacteria.{43139,43140} It inhibits the growth of E. coli, E. faecalis, E. faecium, N. gonorrhoeae, N. meningitidis, P. mirabilis, S. aureus, S. pyogenes, and S. pneumoniae strains (MICs = 0.013-25 μg/ml) and clinical isolates of penicillin-susceptible, -intermediate, and -resistant S. pneumoniae and methicillin-sensitive S. aureus (MIC90s = 0.12-16 μg/ml). In vivo, cefprozil protects mice challenged with E. coli, S. aureus, S. pyogenes, and P. mirabilis strains with protective doses (PD50s) ranging from 0.07 to 1.3 mg/kg.{43139} Cefprozil binds to penicillin-binding proteins (PBPs), which disrupts their ability to cross-link peptidoglycan and leads to weakened bacterial cell walls.{43141} Formulations containing cefprozil have been used in the treatment of respiratory tract, skin, and other bacterial infections.  

 

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SKU: 23840 - 25 mg Category:

Description

A cephalosporin antibiotic; inhibits the growth of both Gram-positive and Gram-negative bacteria; inhibits the growth of E. coli, E. faecalis, E. faecium, N. gonorrhoeae, N. meningitidis, P. mirabilis, S. aureus, S. pyogenes, and S. pneumoniae strains (MICs = 0.013-25 μg/ml) and clinical isolates of penicillin-susceptible, -intermediate, and -resistant S. pneumoniae and methicillin-sensitive S. aureus (MIC90s = 0.12-16 μg/ml); protects mice challenged with E. coli, S. aureus, S. pyogenes, and P. mirabilis strains (PD50s = 0.07-1.3 mg/kg)

Formal name: (6R,7R)-7-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-8-oxo-3-(1-propen-1-yl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Synonyms:  BMY-28100

Molecular weight: 389.4

CAS: 92665-29-7

Purity: ≥95% (mixture of cis and trans)

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Cephalosporins||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Pneumonia||Research Area|Infectious Disease|Bacterial Diseases|STDs

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