An anticholinergic agent; blocks acetylcholine-induced spasm of rat and rabbit intestines ex vivo (ED50s = 0.052 and 0.011 mg/kg

Methylhomatropine (bromide) – 1 g

Brand:
Cayman
CAS:
80-49-9
Storage:
-20
UN-No:
Non-Hazardous - /

Methylhomatropine is an anticholinergic agent.{36327} It blocks spasm of rat and rabbit intestines induced by acetylcholine (Item No. 23829) ex vivo (ED50s = 0.052 and 0.011 mg/kg, respectively). Methylhomatropine slows intestinal transit of a charcoal meal in rats (ED50 = 27 mg/kg) and blocks salivary gland secretion in rabbits (ED50 = 0.16 mg/kg). It also induces mydriasis in mice when administered subcutaneously or orally (ED50s = 0.13 and 12 mg/kg, respectively). Formulations containing methylhomatropine have been used in the treatment of nausea, vomiting, and motion sickness.  

 

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SKU: 23832 - 1 g Category:

Description

An anticholinergic agent; blocks acetylcholine-induced spasm of rat and rabbit intestines ex vivo (ED50s = 0.052 and 0.011 mg/kg, respectively); slows intestinal transit of a charcoal meal in rats (ED50 = 27 mg/kg) and blocks salivary gland secretion in rabbits (ED50 = 0.16 mg/kg); induces mydriasis in mice when administered subcutaneously or orally (ED50s = 0.13 and 12 mg/kg, respectively)

Formal name: (3-endo)-3-[(2-hydroxy-2-phenylacetyl)oxy]-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane, monobromide

Synonyms:  NSC 34399

Molecular weight: 370.3

CAS: 80-49-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Neuroscience|Ophthalmology

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