A 5-HT1A receptor agonist (Ki = 0.4 nM); selective for 5-HT1A over 5-HT1D

U-92016A – 10 mg

Brand:
Cayman
CAS:
149654-41-1
Storage:
-20
UN-No:
Non-Hazardous - /

U-92016A is an agonist of the serotonin (5-HT) receptor subtype 5-HT1A (Ki = 0.4 nM).{39641} It is selective for 5-HT1A over 5-HT1D, 5-HT2, dopamine D1 and D2, and α1- and α2-adrenergic receptors (Kis = 7.7, >1,000, >1,000, 36, >1,000, and >1,000 nM, respectively). U-92016A inhibits forskolin-stimulated cAMP synthesis in CHO cells transfected with human 5-HT1A. In vivo, U-92016A induces hypothermia in mice (ED50 = 0.041 mg/kg). It induces 5-HT syndrome, as measured by increased flat body posture and reciprocal forepaw treading, as well as decreases accumulation of 5-HT and dopamine in rats when administered at a dose of 5 mg/kg. U-92016A also decreases arterial blood pressure and heart rate in a dose-dependent manner in spontaneously hypertensive rats and reverses isolation-induced aggression in mice.  

 

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SKU: 23807 - 10 mg Category:

Description

A 5-HT1A receptor agonist (Ki = 0.4 nM); selective for 5-HT1A over 5-HT1D, 5-HT2, dopamine D1 and D2, and α1- and α2-adrenergic receptors (Kis = 7.7, >1,000, >1,000, 36, >1,000, and >1,000 nM, respectively); inhibits forskolin-stimulated cAMP synthesis in CHO cells transfected with human 5-HT1A; induces hypothermia in mice (ED50 = 0.041 mg/kg); induces 5-HT syndrome as well as decreases accumulation of 5-HT and dopamine in rats (5 mg/kg); decreases arterial blood pressure and heart rate in a dose-dependent manner in spontaneously hypertensive rats; reverses isolation-induced aggression in mice,

Formal name: (8R)-8-(dipropylamino)-6,7,8,9-tetrahydro-3H-benz[e]indole-2-carbonitrile, monohydrochloride

Synonyms: 

Molecular weight: 331.9

CAS: 149654-41-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Neuroscience

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