A prodrug of acyclovir; inhibits HSV-I replication (IC50 = 0.84 µM); rapidly converted to acyclovir in vivo; active against varicella-zoster and Epstein-Barr viruses in vitro (IC50s = 1.3-20.6 and 0.3-25 µM

L-Valacyclovir (hydrochloride) – 250 mg

Brand:
Cayman
CAS:
124832-27-5
Storage:
-20
UN-No:
Non-Hazardous - /

L-Valacyclovir is the L-valyl prodrug of acyclovir (Item No. 14160), an antiviral compound. L-Valacyclovir inhibits herpes simplex virus type I (HSV-I) replication (IC50 = 0.84 µM in Vero cells).{41278} It is more potent than the stereoisomer D-valacyclovir but less potent than acyclovir in vitro, however, it is rapidly converted to acyclovir in vivo.{41279} Formulations containing L-valacyclovir have been used in the treatment of HSV-1 infections.  

 

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SKU: 23801 - 250 mg Category:

Description

A prodrug of acyclovir; inhibits HSV-I replication (IC50 = 0.84 µM); rapidly converted to acyclovir in vivo; active against varicella-zoster and Epstein-Barr viruses in vitro (IC50s = 1.3-20.6 and 0.3-25 µM, respectively)

Formal name: 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]ethyl ester, L-valine, monohydrochloride

Synonyms:  BW 256U|BW 256U87

Molecular weight: 360.8

CAS: 124832-27-5

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Antivirals|DNA & RNA Polymerase Inhibitors||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HSV

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