An azole antifungal; active against dermatophyte fungal species

Sulconazole (nitrate) – 100 mg

Brand:
Cayman
CAS:
61318-91-0
Storage:
-20
UN-No:
Non-Hazardous - /

Sulconazole is an azole antifungal that is active against dermatophyte fungal species, including isolates of various Candida species.{38783} It acts as a non-specific inhibitor of styrene metabolism by cytochrome P450 (CYP450) enzymes, with Ki values ranging from 0.008 to 3.5 µM against various CYP450 isoforms in human lymphoblast microsomes in vitro.{38782,38784} In rat spleen microsomes, it inhibits the activity of heme oxygenase 1 with an IC50 value of 1.1 µM.{24647} Sulconazole inhibits DNA damage induced by the metabolism of styrene by bacterial CYP450cam with a Ki value of 204.2 μM in an electrochemical biosensor model.{38782} Formulations containing sulconazole have been used for the treatment of fungal infections.  

 

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SKU: 23800 - 100 mg Category:

Description

An azole antifungal; active against dermatophyte fungal species, including isolates of various Candida species; non-specific inhibitor of styrene metabolism by cytochrome P450 (CYP450) enzymes; inhibits various CYP450 isoforms in human lymphoblast microsomes in vitro (Kis = 0.008-3.5 µM); inhibits heme oxygenase 1 activity in rat spleen microsomes (IC50 = 1.1 µM); inhibits DNA damage induced by styrene metabolism by bacterial CYP450cam (Ki = 204.2 μM)

Formal name: 1-[2-[[(4-chlorophenyl)methyl]thio]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, mononitrate

Synonyms:  RS 44872

Molecular weight: 460.8

CAS: 61318-91-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antifungals|Imidazoles||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Fungal Diseases|Candidiasis

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