A synthetic glucocorticoid with anti-inflammatory properties; inhibits edema by 55% in a RPA test in rabbit when administered topically (0.1% w/w); inhibits edema by 70.1% and 88.0% in croton oil-induced and PCA tests

Halcinonide – 50 mg

Brand:
Cayman
CAS:
3093-35-4
Storage:
-20
UN-No:
Non-Hazardous - /

Halcinonide is a synthetic glucocorticoid with anti-inflammatory properties.{40483,40484} In a rabbit model of edema, topical application of halcinonide (0.1% w/w) decreases edema by 55% in a reversed passive Arthus skin test (RPA).{40483} Halcinonide (0.1% w/w) inhibits croton oil-induced ear edema by 70.1% and homologous passive cutaneous anaphylaxis (PCA) by 88.0% in rats dosed three hours prior to induction of inflammation.{40484} Application of halcinonide (0.1% w/w) to the abraded surface of cecum in rats inhibits leukocyte adhesion (43.3% incidence versus 100% for controls) and lowers the total number of intraperitoneal leukocytes from 270 million to 121 million 3 days post surgery.{40485} It also acts as an agonist at the smoothened (Smo) receptor with an EC50 value of 1,100 nM.{40486} Formulations containing halcinonide have been used to treat inflammatory and corticosteroid-responsive dermatoses.  

 

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Description

A synthetic glucocorticoid with anti-inflammatory properties; inhibits edema by 55% in a RPA test in rabbit when administered topically (0.1% w/w); inhibits edema by 70.1% and 88.0% in croton oil-induced and PCA tests, respectively, in rat (topical, 0.1% w/w); in vivo application (0.1% w/w) to the abraded surface of cecum in rats inhibits leukocyte adhesion (43.3% incidence versus 100% for controls) and lowers the total number of intraperitoneal leukocytes from 270 million to 121 million 3 days post surgery; acts as an agonist at the Smo receptor (EC50 = 1,100 nM)

Formal name: 21-chloro-9-fluoro-11β-hydroxy-16α,17-[(1-methylethylidene)bis(oxy)]-pregn-4-ene-3,20-dione

Synonyms:  SQ 18,566

Molecular weight: 455

CAS: 3093-35-4

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Glucocorticoids & Mineralocorticoids||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Gastric Disease||Research Area|Immunology & Inflammation|Innate Immunity

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