A synthetic precursor and prodrug of norepinephrine; increases norepinephrine levels in the rat heart following intraperitoneal administration and in the brain following intracerebroventricular administration at doses of 125 and 100 µg/animal

Droxidopa – 5 mg

Brand:
Cayman
CAS:
23651-95-8
Storage:
-20
UN-No:
Non-Hazardous - /

Droxidopa (L-DOPS) is a synthetic precursor and prodrug of the neurotransmitter norepinephrine.{40480} It is transformed into norepinephrine through the action of DOPA decarboxylase. L-DOPS increases norepinephrine levels in the rat heart following intraperitoneal administration and in the brain following intracerebroventricular administration at doses of 125 and 100 µg/animal, respectively. It increases arterial pressure and mesenteric arterial resistance in rats with ligated portal vein or biliary ducts when used at doses of 25-50 mg/kg.{40481} L-DOPS crosses the blood brain barrier, however, its effects can be blocked by the peripherally-restricted DOPA decarboxylase inhibitor carbidopa (Item No. 23783), indicating that the mechanism is peripheral.{40482,40481} Formulations containing droxidopa are used in the treatment of neurogenic orthostatic hypotension.  

 

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SKU: 23779 - 5 mg Category:

Description

A synthetic precursor and prodrug of norepinephrine; increases norepinephrine levels in the rat heart following intraperitoneal administration and in the brain following intracerebroventricular administration at doses of 125 and 100 µg/animal, respectively; increases arterial pressure and mesenteric arterial resistance in rats with ligated portal vein or biliary ducts when used at doses of 25-50 mg/kg; crosses the blood brain barrier but works through a peripheral mechanism

Formal name: (βR),3-dihydroxy-L-tyrosine

Synonyms:  L-threo-3,4-Dihydroxyphenylserine|L-Dihydroxyphenylserine|L-DOPS|SM 5688

Molecular weight: 213.2

CAS: 23651-95-8

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypotension

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