A muscarinic acetylcholine receptor antagonist (Kis = 15.8

Fesoterodine (fumarate) – 10 mg

Brand:
Cayman
CAS:
286930-03-8
Storage:
-20
UN-No:
Non-Hazardous - /

Fesoterodine is an antagonist of muscarinic acetylcholine receptors (Kis = 15.8, 11.2, 12.6, 22.4, and 25.1 nM for human M1-5, respectively).{41347} In vivo, fesoterodine (0.01 mg/kg, i.v.) reduces micturition pressure and increases bladder capacity and intercontraction interval (ICI) in conscious female rats. Fesoterodine also reduces intermicturition pressure and prevents bladder overactivity in a rat model of spinal cord injury-induced overactive bladder.{41348}  

 

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SKU: 23777 - 10 mg Category:

Description

A muscarinic acetylcholine receptor antagonist (Kis = 15.8, 11.2, 12.6, 22.4, and 25.1 nM for human M1-5, respectively); reduces micturition pressure and increases bladder capacity and ICI in conscious female rats when administered at a dose of 0.01 mg/kg; reduces intermicturition pressure and prevents bladder overactivity in a rat model of spinal cord injury-induced overactive bladder

Formal name: 2-methyl-propanoic acid, 2-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenyl ester, (2E)-2-butenedioate

Synonyms:  SMP 8272|SPM 907

Molecular weight: 527.7

CAS: 286930-03-8

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience

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