A β-adrenergic receptor antagonist (Kd = 13 nM); blocks isoproterenol-induced increases in heart rate

Carteolol (hydrochloride) – 100 mg

Brand:
Cayman
CAS:
51781-21-6
Storage:
-20
UN-No:
Non-Hazardous - /

Carteolol is an antagonist of β-adrenergic receptors (Kd = 13 nM).{38754,38755} It blocks isoproterenol-induced increases in heart rate, contractile force, and blood pressure in vagotomized dogs (ED50s = 2.3, 3.1, and 1.8 µg/kg, respectively).{38756} The (R) and (S)-enantiomers of carteolol reduce intraocular pressure to similar levels in rabbits when applied topically as a 1% solution.{38757} Formulations containing carteolol have been used in the treatment of open-angle glaucoma.  

 

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Description

A β-adrenergic receptor antagonist (Kd = 13 nM); blocks isoproterenol-induced increases in heart rate, contractile force, and blood pressure in vagotomized dogs (ED50s = 2.3, 3.1, and 1.8 µg/kg, respectively); the (R) and (S)-enantiomers each reduce intraocular pressure in rabbits (1% solution)

Formal name: 5-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-3,4-dihydro-2(1H)-quinolinone, monohydrochloride

Synonyms:  NSC 300906|OPC 1085

Molecular weight: 328.8

CAS: 51781-21-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Heart|Arrhythmia||Research Area|Cardiovascular System|Heart|Myocardial Contractility||Research Area|Neuroscience|Ophthalmology

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