A broad-spectrum anticancer agent; active against a panel of 21 cancer cell lines (IC50s = 1.4-34.5 nM); stabilizes and induces the polymerization of microtubules and induces cell cycle arrest during mitosis; cytotoxic to paclitaxel-resistant HCT116/VM46 and A2780Tax clonogenic cells (IC90s = 16 and 12.3 nM

Ixabepilone – 10 mg

Brand:
Cayman
CAS:
219989-84-1
Storage:
-20
UN-No:
- /

Ixabepilone is an epothilone with broad-spectrum anticancer activity against a panel of 21 cancer cell lines (IC50s = 1.4-34.5 nM).{42060} It stabilizes and induces the polymerization of microtubules and induces cell cycle arrest during mitosis. Ixabepilone is cytotoxic to HCT116/VM46 and A2780Tax clonogenic cells, which are resistant to paclitaxel (Item No. 10461; IC90s = 16 and 12.3 nM, respectively, for colony growth inhibition). In vivo, ixabepilone (6.3 and 10 mg/kg, i.v., respectively) shows antitumor activity in paclitaxel-resistant human Pat-21 breast carcinoma and HCT116/VM46 colon carcinoma mouse xenograft models with log cell kill (LCK) values of 1.6 and 2.4, respectively. Ixabepilone (10 mg/kg, i.v.) also increases the time for tumors to quadruple in volume by 7.2, 9, 6.5, 4.7, and >10 weeks, respectively, in mice implanted with Rh18 rhabdomyosarcoma, NB1643 neuroblastoma, WT5 Wilms’ tumor, OS29 osteosarcoma, and BT29 brain carcinoma cells.{42061} Formulations containing ixabepilone have used in the treatment of metastatic breast cancer.{26908}  

 

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Description

A broad-spectrum anticancer agent; active against a panel of 21 cancer cell lines (IC50s = 1.4-34.5 nM); stabilizes and induces the polymerization of microtubules and induces cell cycle arrest during mitosis; cytotoxic to paclitaxel-resistant HCT116/VM46 and A2780Tax clonogenic cells (IC90s = 16 and 12.3 nM, respectively, for colony growth inhibition); shows antitumor activty in paclitaxel-resistant human Pat-21 breast carcinoma and HCT116/VM46 colon carcinoma mouse xenograft models (LCKs = 1.6 and 2.4, respectively); increases the time for tumors to quadruple in volume in mice implanted with Rh18 rhabdomyosarcoma, NB1643 neuroblastoma, WT5 Wilms’ tumor, OS29 osteosarcoma, and BT29 brain carcinoma cells at 10 mg/kg ,

Formal name: (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione

Synonyms:  Azaepothilone B|BMS-247550

Molecular weight: 506.7

CAS: 219989-84-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Microtubule Dynamics||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Death

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