A muscarinic M2 and M3 receptor antagonist (Kis = 0.68 and 2.6 nM

Mepenzolate (bromide) – 1 g

Brand:
Cayman
CAS:
76-90-4
Storage:
-20
UN-No:
Non-Hazardous - /

Mepenzolate is an antagonist of muscarinic (M) acetylcholine receptors (Kis = 0.68 and 2.6 nM for human M2 and M3 receptors, respectively).{41272} It has antispasmodic activity in the gastrointestinal tract of anesthetized cats and dogs when administered at a dose of 0.5 mg/kg.{41273} Mepenzolate decreases airspace enlargement induced by elastase or cigarette smoke and reduces respiratory dysfunction in a mouse model of chronic obstructive pulmonary disease (COPD).{41274} It also reduces oxidative stress, decreases the expression of IL-1β, IL-6, and TNF-α, and increases the expression of TGF-β1, IGF-1, and VEGF in a diabetic wound healing mouse model.{41275}  

 

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SKU: 23717 - 1 g Category:

Description

A muscarinic M2 and M3 receptor antagonist (Kis = 0.68 and 2.6 nM, respectively); has antispasmodic activity in cats and dogs when administered at a dose of 0.5 mg/kg; decreases airspace enlargement induced by elastase or cigarette smoke in a mouse model of COPD; reduces oxidative stress, decreases the expression of pro-inflammatory cytokines, and increases the expression of anti-inflammatory cytokines in a mouse model of diabetic wound healing

Formal name: 3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-1,1-dimethyl-piperidinium, monobromide

Synonyms:  NSC 4358

Molecular weight: 420.3

CAS: 76-90-4

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Immunology & Inflammation|Pulmonary Diseases|COPD/Emphysema||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity

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