A nucleoside analog with antiviral properties; inhibits replication of laboratory and clinical isolate wild-type and polV74 mutant HIV viruses in PBMCs (IC50s = 0.3-1.4 and 1.1-11.2 μM for wild-type and pol74 mutant strains

Didanosine – 250 mg

Brand:
Cayman
CAS:
69655-05-6
Storage:
-20
UN-No:
Non-Hazardous - /

Didanosine is a nucleoside analog with antiviral properties.{38655} It undergoes cellular phosphorylation to its active triphosphate form, 2′,3′-dideoxyadenosine 5′-triphosphate (ddATP; Item No. 17460). Didanosine inhibits replication of laboratory and clinical isolate wild-type and polV74 mutant HIV viruses in peripheral blood mononuclear cells (PBMCs; IC50s = 0.3-1.4 and 1.1-11.2 μM for wild-type and pol74 mutant strains, respectively).{38655,38656} Didanosine dose-dependently decreases cell proliferation and differentiation, induces accumulation of cytoplasmic lipid droplets, increases lactate production, decreases cytochrome c oxidase (complex IV) and succinate dehydrogenase (SDH) activity, and inhibits mitochondrial function in primary human muscle cells.{38657} In vivo, didanosine decreases the number of HIV-infected mice (IC50 = 13.7 mg/kg per day, i.p. starting the day before infection with HIV) in a SCID-hu mouse model of human hematolymphoid engrafted organs.{38655,38658} Formulations containing didanosine in combination with highly active antiretroviral therapy (HAART) have been used to treat HIV infection.  

 

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SKU: 23715 - 250 mg Category:

Description

A nucleoside analog with antiviral properties; inhibits replication of laboratory and clinical isolate wild-type and polV74 mutant HIV viruses in PBMCs (IC50s = 0.3-1.4 and 1.1-11.2 μM for wild-type and pol74 mutant strains, respectively); decreases the number of HIV-infected mice (IC50 = 13.7 mg/kg per day, i.p. starting the day before infection with HIV) in a SCID-hu mouse model of human hematolymphoid engrafted organs

Formal name: 2′,3′-dideoxy-inosine

Synonyms:  2′,3′-Dideoxyinosine|ddl|NSC 612049

Molecular weight: 236.2

CAS: 69655-05-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Nucleotides/Nucleosides||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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