A prodrug of T-91825

TAK-599 – 10 mg

Brand:
Cayman
CAS:
400827-46-5
Storage:
-20
UN-No:
Non-Hazardous - /

TAK-599 is a prodrug of T-91825, a cephalosporin antibiotic.{37238} In vitro, TAK-599 inhibits growth of S. pneumoniae, S. aureus, methicillin-resistant S. aureus (MRSA), E. coli, and K. pneumoniae (MICs = 0.008-2 mg/L).{37240} It is rapidly converted to T-91825 in rats and monkeys.{37238} TAK-599 has bacteriostatic effects in mice infected with S. pneumoniae, S. aureus, MRSA, E. coli, or K. pneumoniae when administered at doses ranging from 0.2-234 mg/kg per day and also decreases the number of CFUs in a mouse model of thigh infection.{37240} It exhibits a protective effect against systemic infection by clinical MRSA isolates in mice (ED50s = 1.08-4.81 mg/kg).{37239}  

 

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SKU: 23696 - 10 mg Category:

Description

A prodrug of T-91825, a cephalosporin antibiotic; inhibits growth of S. pneumoniae, S. aureus, MSRA, E. coli, and K. pneumoniae in vitro (MICs = 0.008-2.0 mg/L); rapidly converted in vivo to T-91825 in rats and monkeys; has a bacteriostatic effect on S. pneumoniae, S. aureus, MSRA, E. coli, and K. pneumoniae in vivo when administered at doses ranging from 0.2-234 mg/kg per day; decreases the number of CFUs in a mouse model of thigh infection; exhibits a protective effect against systemic infection by clinical MRSA isolates in mice (ED50s = 1.08-4.81 mg/kg)

Formal name: 4-[2-[[(6R,7R)-2-carboxy-7-[[(2Z)-2-(ethoxyimino)-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]thio]-4-thiazolyl]-1-methyl-pyridinium, monoacetate

Synonyms: 

Molecular weight: 744.7

CAS: 400827-46-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Cephalosporins||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|MRSA||Research Area|Infectious Disease|Bacterial Diseases|Pneumonia

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