Description
A γ-glutamylcysteine synthetase inhibitor (100% inhibition at a concentration of 10 μM in an enzyme assay); selective for γ-glutamylcysteine synthetase, lacking activity at glutamine synthetase at concentrations up to 500 μM; reduces renal glutathione in mice without inducing abnormal behavior or convulsions at a dose of 32 mmol/kg; eliminates T. brucei from the bloodstream of infected mice via depletion of intratrypanosomal glutathione and induction of oxidative stress at a dose of 4 mmol/kg; an isomeric mixture of L-buthionine-S-sulfoxime, L-buthionine-R-sulfoxime, D-buthionine-S-sulfoxime, and D-buthionine-R-sulfoxime
Formal name: 2-amino-4-(S-butylsulfonimidoyl)-butanoic acid
Synonyms: NSC 381100
Molecular weight: 222.3
CAS: 5072-26-4
Purity: ≥98%
Formulation: A solid
Product Type|Biochemicals|Small Molecule Inhibitors|Amino Acid Turnover||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases|African Sleeping Sickness||Research Area|Oxidative Stress & Reactive Species|Pro-oxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione
