An inhibitor of purine synthesis and interconversion; rapidly converted to 6-mercaptopurine ribonucleoside-5'-monophosphate

6-Mercaptopurine (hydrate) – 5 g

Brand:
Cayman
CAS:
6112-76-1
Storage:
-20
UN-No:
Non-Hazardous - /

6-Mercaptopurine (6-MP) is an inhibitor of purine synthesis and interconversion.{36297} It is rapidly converted to 6-mercaptopurine ribonucleoside-5′-monophosphate, which inhibits phosphoribosyl pyrophosphate (PRPP) amidotransferase, the rate-limiting enzyme in purine synthesis. It also inhibits the conversion of IMP to adenylosuccinic acid and xanthylic acid and blocks AMP formation in vitro. 6-MP (30 mg/kg) inhibits growth of sarcoma 180, adenocarcinoma E 0771, and adenocarcinoma 755 tumors and reduces the size of leukemia L1210 subcutaneous growths in mice.{36298} It also decreases delayed-type hypersensitivity and thyroid inflammation in a guinea pig model of thyroiditis when administered pre- or post-disease onset.{36299} Formulations containing mercaptopurine have been used for maintenance therapy in patients with acute lymphoblastic leukemia.{36300}  

 

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Description

An inhibitor of purine synthesis and interconversion; rapidly converted to 6-mercaptopurine ribonucleoside-5′-monophosphate, which inhibits PRPP amidotransferase, the conversion of IMP to adenylosuccinic acid and xanthylic acid, and blocks AMP formation in vitro; inhibits growth of sarcoma 180, adenocarcinoma E 0771, and adenocarcinoma 755 tumors and reduces the size of leukemia L1210 subcutaneous growths in mice when administered at a dose of 30 mg/kg; decreases delayed-type hypersensitivity and thyroid inflammation in a guinea pig model of thyroiditis when administered pre- or post-disease onset

Formal name: 1,2,3,9-tetrahydro-6H-purine-6-thione, monohydrate

Synonyms:  6-MP

Molecular weight: 170.2

CAS: 6112-76-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Cancer|DNA Damage and Repair||Research Area|Immunology & Inflammation|Autoimmunity

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