A natural steroid glycoside with diverse effects; inhibits production of IL-1β

Ginsenoside Rf – 10 mg

Brand:
Cayman
CAS:
52286-58-5
Storage:
4
UN-No:
Non-Hazardous - /

Ginsenoside Rf is a steroid glycoside found in plants of the genus Panax that has diverse biological activities.{36223,36224,36225,36226} It inhibits production of IL-1β, IL-6, TNF-α, NO, and reactive oxygen species (ROS) in human HT-29 intestinal epithelial cells and RAW 264.7 mouse macrophages in a dose-dependent manner.{36224} Ginsenoside Rf inhibits N-type calcium channels in rat sensory neurons (IC50 = 40 μM).{36223} In vivo, ginsenoside Rf has antinociceptive effects in mice in the acetic acid abdominal constriction test and in the biphasic formalin test (ED50s = 56 and 129 mg/kg, respectively), which are models of tonic pain.{36225} Topical administration of ginsenoside Rf (0.05% solution) reduces ear swelling by 34.8% in a mouse model of contact dermatitis.{36226}  

 

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SKU: 23667 - 10 mg Category:

Description

A natural steroid glycoside with diverse effects; inhibits production of IL-1β, IL-6, TNF-α, NO, and ROS in HT-29 and RAW 264.7 cells in a dose-dependent manner; inhibits N-type calcium channels in rat sensory neurons (IC50 = 40 μM); has antinociceptive effects in mice in the acetic acid abdominal constriction test and in the biphasic formalin test (ED50s = 56 and 129 mg/kg, respectively); reduces ear swelling by 34.8% in a mouse model of contact dermatitis

Formal name: 3β,12β,20-trihydroxydammar-24-en-6α-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside

Synonyms: 

Molecular weight: 801

CAS: 52286-58-5

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Natural Products|Glycosides||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Neuroscience|Pain Research

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