An antifungal agent; inhibits the growth of wild-type fission yeast cells (MIC = 0.13-0.28 μM); induces abnormal accumulation of cell wall material in wild-type fission yeast cells; lacks activity against Gram-positive bacteria and human HeLa and MDA-MB-231 cancer cell lines; induces reversible morphological changes in HeLa cells at a concentration of 20 μM

Heronamide C – 5 mg

Brand:
Cayman
CAS:
1257083-94-5
Storage:
-20
UN-No:
Non-Hazardous - /

Heronamide C is a polyketide macrolactam antifungal agent produced by marine Actinomycetes.{40465} It inhibits the growth of and induces abnormal accumulation of cell wall material in wild-type fission yeast cells (MIC = 0.13-0.28 μM). Heronamide C lacks activity against Gram-positive bacteria and human HeLa and MDA-MB-231 cancer cell lines.{40466} However, it induces reversible morphological changes, including formation of large intracellular structures, in HeLa cells at a concentration of 20 μM.  

 

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Description

An antifungal agent; inhibits the growth of wild-type fission yeast cells (MIC = 0.13-0.28 μM); induces abnormal accumulation of cell wall material in wild-type fission yeast cells; lacks activity against Gram-positive bacteria and human HeLa and MDA-MB-231 cancer cell lines; induces reversible morphological changes in HeLa cells at a concentration of 20 μM

Formal name: 9S,10R-dihydroxy-7,15-dimethyl-20R-(2E,4E)-2,4-octadien-1-yl-,azacycloeicosa-3E,5E,7E,11Z,13E,15E,17E-heptaen-2-one

Synonyms: 

Molecular weight: 449.6

CAS: 1257083-94-5

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Natural Products|Polyketides||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Fungal Diseases

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