An L- and T-type calcium channel blocker; blocks recombinant rabbit L-type (α1Cα2/δβ1a) and human T-type (α1H) calcium channels expressed in Xenopus oocytes; blocks native L-type channels in dissociated guinea pig cardiac ventricular cells (IC50 = 2.6 nM); inhibits ET-1-induced increases in intracellular calcium in A7r5 rat vascular smooth muscle cells (ED50 = 1 nM); inhibits potassium-induced contraction of isolated dog femoral and portal veins (IC50s = 24 and 2.1 nM

Manidipine – 25 mg

Brand:
Cayman
CAS:
89226-50-6
Storage:
-20
UN-No:
Non-Hazardous - /

Manidipine is a dihydropyridine L- and T-type calcium channel blocker.{39642,39643,39644} It blocks recombinant rabbit L-type (α1Cα2/δβ1a) and human T-type (α1H) calcium channels expressed in Xenopus oocytes and native L-type channels in dissociated guinea pig cardiac ventricular cells (IC50 = 2.6 nM). Manidipine inhibits intracellular calcium increases induced by endothelin-1 (ET-1; Item No. 24127) in A7r5 rat vascular smooth muscle cells (ED50 = 1 nM) and potassium-induced contraction of isolated dog femoral and portal veins (IC50s = 24 and 2.1 nM, respectively).{39645,39646} In vivo, it lowers blood pressure in spontaneously hypertensive rats (SHRs) when administered at a dose of 10 mg/kg and inhibits left ventricular hypertrophy in rats induced by isoproterenol (Item No. 15592) when administered at a dose of 3 mg/kg.{39647,39648} Formulations containing manidipine have been used in the treatment of hypertension.  

 

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SKU: 23614 - 25 mg Category:

Description

An L- and T-type calcium channel blocker; blocks recombinant rabbit L-type (α1Cα2/δβ1a) and human T-type (α1H) calcium channels expressed in Xenopus oocytes; blocks native L-type channels in dissociated guinea pig cardiac ventricular cells (IC50 = 2.6 nM); inhibits ET-1-induced increases in intracellular calcium in A7r5 rat vascular smooth muscle cells (ED50 = 1 nM); inhibits potassium-induced contraction of isolated dog femoral and portal veins (IC50s = 24 and 2.1 nM, respectively); lowers blood pressure in SHRs (10 mg/kg); inhibits isoproterenol-induced left ventricular hypertrophy in rats (3 mg/kg)

Formal name: 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] 5-methyl ester

Synonyms:  (±)-Manidipine|CV-4093|Franidipine

Molecular weight: 610.7

CAS: 89226-50-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Heart|Myocardial Contractility||Research Area|Cardiovascular System|Heart|Myocardial Hypertrophy||Research Area|Cardiovascular System|Vasculature|Vasodilation

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