A sulfonamide antibiotic; inhibits growth of E. coli (MIC = 10 μg/ml) and clinical MRSA isolates (MICs = 25-50 μg/ml); inhibits growth of MRSA in vivo in mice when administered in combination with trimethoprim (MIC = 0.8 μg/ml

Sulfamethoxazole – 100 g

Brand:
Cayman
CAS:
723-46-6
Storage:
-20
UN-No:
Non-Hazardous - /

Sulfamethoxazole is a sulfonamide antibiotic.{38582} It inhibits growth of E. coli (MIC = 10 μg/ml) and clinical isolates of methicillin-resistant S. aureus (MRSA; MICs = 25-50 μg/ml).{38583,38584} Sulfamethoxazole, in combination with trimethoprim (Item No. 16473) at a ratio of 20:1, inhibits growth of MRSA in vivo in mice (MIC = 0.8 μg/ml; ED50s = 6.4 and 9.6 mg/kg for two MRSA strains).{38584} In a mouse model of urinary tract infection with E. coli, a combination of sulfamethoxazole and trimethoprim decreases recurrent infection when administered for 10 days.{38585} Sulfamethoxazole acts by inhibiting dihydropteroate synthase (DHPS), which converts a pteridine and 4-aminobenzoic acid (PABA; Item No. 18659) to dihydropteroate, an intermediate in folate biosynthesis. It inhibits recombinant P. carinii DHPS (IC50 = 23 nM; Ki = 7.5 nM) and folate biosynthesis in situ by 48.6%. Formulations containing sulfamethoxazole and trimethoprim have been used to treat bronchitis, prostatitis, and urinary tract infections among other infectious conditions.  

 

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SKU: 23613 - 100 g Category:

Description

A sulfonamide antibiotic; inhibits growth of E. coli (MIC = 10 μg/ml) and clinical MRSA isolates (MICs = 25-50 μg/ml); inhibits growth of MRSA in vivo in mice when administered in combination with trimethoprim (MIC = 0.8 μg/ml, ED50s = 6.4 and 9.6 mg/kg for two MRSA strains); acts by inhibiting DHPS; inhibits recombinant P. carinii DHPS (IC50 = 23 nM; Ki = 7.5 nM) and folate biosynthesis in situ by 48.6%; decreases recurrent infection in a mouse model of urinary tract infection with E. coli when administered in combination with trimethoprim

Formal name: 4-amino-N-(5-methyl-3-isoxazolyl)-benzenesulfonamide

Synonyms:  NSC 147832|Ro 4-2130

Molecular weight: 253.3

CAS: 723-46-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Sulfonamides||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|MRSA

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