A long-acting β2-AR agonist with bronchodilator actions; inhibits TGF-α-induced hepatocyte DNA syntheses and proliferation in vitro (IC50 = 15 nM); dose-dependently relaxes lung strips and increases heart rate and inotropy of right atria and left atria

Metaproterenol (hemisulfate) – 50 mg

Brand:
Cayman
CAS:
5874-97-5
Storage:
-20
UN-No:
Non-Hazardous - /

Metaproterenol is a β2-adrenergic receptor (β2-AR) agonist with bronchodilator actions.{40372} It inhibits TGF-α-induced hepatocyte DNA synthesis and proliferation in vitro (IC50 = 15 nM), an effect that is reversed by the β2-AR antagonist butoxamine but not the β1-AR antagonist metoprolol (Item No. 15429).{40371} Metaproterenol dose-dependently relaxes lung strips and increases heart rate and inotropy of right atria and left atria, respectively, isolated from guinea pig (pD2s = 6.4, 7.08, and 6.61, respectively).{40373} Formulations containing metaproterenol were previously used as long-acting bronchodilators for the treatment of asthma.  

 

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Description

A long-acting β2-AR agonist with bronchodilator actions; inhibits TGF-α-induced hepatocyte DNA syntheses and proliferation in vitro (IC50 = 15 nM); dose-dependently relaxes lung strips and increases heart rate and inotropy of right atria and left atria, respectively, isolated from guinea pig (pD2s = 6.4, 7.08, and 6.61, respectively)

Formal name: 5-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]-1,3-benzenediol, hemisulfate

Synonyms:  dl-Metaproterenol|dl-Orciprenaline

Molecular weight: 260.3

CAS: 5874-97-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Immunology & Inflammation|Pulmonary Diseases|Asthma

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