An anticholinergic agent; inhibits acetylcholine-induced contraction of isolated guinea pig ileum and reduces intensity of vagal-stimulated gastric contractions in rats; increases gastric pH and prevents pyloric ligature-induced gastric ulcer formation in Shay rats when administered at a dose of 5 mg/kg

Propantheline (bromide) – 1 g

Brand:
Cayman
CAS:
50-34-0
Storage:
-20
UN-No:
Non-Hazardous - /

Propantheline is an anticholinergic agent.{41353,41354,41355} It inhibits contraction of isolated guinea pig ileum induced by acetylcholine (Item No. 23829) and reduces intensity of vagal-stimulated gastric contractions in rats.{41353} Propantheline (5 mg/kg, s.c.) increases gastric pH and prevents pyloric ligature-induced gastric ulcer formation in Shay rats.{41354} It also inhibits basal and pentagastrin-, but not histamine-, stimulated gastric secretion in a rhesus monkey model of chronic gastric fistula.{41355} Formulations containing propantheline have been used to treat stomach and intestinal spasms associated with irritable bowel syndrome.  

 

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SKU: 23609 - 1 g Category:

Description

An anticholinergic agent; inhibits acetylcholine-induced contraction of isolated guinea pig ileum and reduces intensity of vagal-stimulated gastric contractions in rats; increases gastric pH and prevents pyloric ligature-induced gastric ulcer formation in Shay rats when administered at a dose of 5 mg/kg, s.c.; inhibits basal and pentagastrin-, but not histamine-, stimulated gastric secretion in a rhesus monkey model of chronic gastric fistula

Formal name: N-methyl-N-(1-methylethyl)-N-[2-[(9H-xanthen-9-ylcarbonyl)oxy]ethyl]-2-propanaminium, monobromide

Synonyms:  SC-3171

Molecular weight: 448.4

CAS: 50-34-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Immunology & Inflammation|Gastric Disease

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