A partial agonist of GABAB receptors (IC50 = 1.5 μM in a radioligand binding assay); induces relaxation in unstimulated isolated guinea pig ileum longitudinal muscle; completely inhibits GABA- and baclofen-induced inhibition of vagally stimulated bronchospasms in guinea pigs (5 mg/kg); reverses the antitussive effect of baclofen in cats (3 mg/kg)

3-Aminopropylphosphonic Acid – 100 mg

Brand:
Cayman
CAS:
13138-33-5
Storage:
-20
UN-No:
Non-Hazardous - /

3-Aminopropylphosphonic acid (3-APPA) is a phosphonic analog of GABA that acts as a partial agonist of GABAB receptors (IC50 = 1.5 μM in a radioligand binding assay).{36477,23832} It induces relaxation in unstimulated isolated guinea pig ileum longitudinal muscle and reverses GABA- and baclofen-induced inhibition of twitch responses in isolated guinea pig ileum longitudinal muscle.{36477} 3-APPA (5 mg/kg) completely inhibits GABA- and baclofen-induced inhibition of vagally stimulated bronchospasms in guinea pigs.{36478} It also reverses the antitussive effect of baclofen in cats when administered at a dose of 3 mg/kg.{36479}  

 

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SKU: 23556 - 100 mg Category:

Description

A partial agonist of GABAB receptors (IC50 = 1.5 μM in a radioligand binding assay); induces relaxation in unstimulated isolated guinea pig ileum longitudinal muscle; completely inhibits GABA- and baclofen-induced inhibition of vagally stimulated bronchospasms in guinea pigs (5 mg/kg); reverses the antitussive effect of baclofen in cats (3 mg/kg)

Formal name: P-(3-aminopropyl)-phosphonic acid

Synonyms:  3-APPA|NSC 133832|β-Aminopropylphosphonic Acid

Molecular weight: 139.1

CAS: 13138-33-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience

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