A D1 and D2 receptor antagonist (Kis = 5 and 0.63 nM

Fluphenazine (hydrochloride) – 1 g

Brand:
Cayman
CAS:
146-56-5
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Fluphenazine is a dopamine D1 and D2 receptor antagonist (Kis = 5 and 0.63 nM, respectively).{40356} It also binds to histamine H1, serotonin 5-HT2A, and 5-HT2B receptors (Kis = 45, 17, and 82 nM, respectively).{40357} It acts as an inverse agonist at H1 and 5-HT2A receptors.{40357,40358} Fluphenazine is a typical antipsychotic compound. It induces extrapyramidal symptoms in animal models, including monkeys.{40359} Formulations containing fluphenazine have been used in the management of psychotic disorders.  

 

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SKU: 23555 - 1 g Category:

Description

A D1 and D2 receptor antagonist (Kis = 5 and 0.63 nM, respectively); binds to histamine H1, serotonin 5-HT2A, and 5-HT2B receptors (Kis = 45, 17, and 82 nM, respectively); acts as an inverse agonist at H1 and 5-HT2A receptors; a typical antipsychotic compound that induces extrapyramidal symptoms in monkeys

Formal name: 4-[3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-1-piperazineethanol, dihydrochloride

Synonyms:  SQ 4,918

Molecular weight: 510.4

CAS: 146-56-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Receptor Pharmacology|Inverse Agonists||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis

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