An activator of carbamoyl phosphate synthetase 1; reduces 2-ketoisocaproate-induced hyperammonemia in a mouse model of 3-hydroxy-3-methylglutaryl-CoA lyase deficiency when used at a dose of 500 mg/kg; inhibits cancer cell proliferation (IC50s = 5-7.5 nM) and tumor growth (120 mg/kg per day for 10 days) in mouse models of pancreatic and breast cancer

N-Carbamyl-L-Glutamic Acid – 5 g

Brand:
Cayman
CAS:
1188-38-1
Storage:
22
UN-No:
Non-Hazardous - /

N-Carbamyl-L-glutamic acid is an activator of carbamoyl phosphate synthetase 1 (CPS1), the first enzyme in the urea cycle.{38610} It is a structural analog of N-acetyl-glutamate, an endogenous CPS1 activator. N-Carbamyl-L-glutamic acid (500 mg/kg) reduces 2-ketoisocaproate-induced hyperammonemia in a mouse model of 3-hydroxy-3-methylglutaryl-CoA lyase deficiency.{38609} It inhibits cell proliferation of a variety of cancer cell lines with IC50 values ranging from 5 to 7.5 nM.{38608} It also inhibits tumor growth by 80 and 82% in orthotopic mouse models of pancreatic and triple-negative breast cancer, respectively, when administered at a dose of 120 mg/kg per day for 10 days. Formulations containing N-carbamyl-L-glutamic acid have been used in the treatment of primary N-acetyl-glutamate synthase deficiency.  

 

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Description

An activator of carbamoyl phosphate synthetase 1; reduces 2-ketoisocaproate-induced hyperammonemia in a mouse model of 3-hydroxy-3-methylglutaryl-CoA lyase deficiency when used at a dose of 500 mg/kg; inhibits cancer cell proliferation (IC50s = 5-7.5 nM) and tumor growth (120 mg/kg per day for 10 days) in mouse models of pancreatic and breast cancer

Formal name: N-(aminocarbonyl)-L-glutamic acid

Synonyms:  Carglumic Acid

Molecular weight: 190.2

CAS: 1188-38-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Inborn Errors of Metabolism

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